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ABSTRACT: Glucagon-like peptide-1 (GLP-1) receptor agonists are an increasingly popular class of glucose-lowering agents for the treatment of type 2 diabetes (T2DM), owing to their robust glucose-lowering effects, low risk of hypoglycemia, and potential to induce weight loss

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Before choosing between injectable Wegovy and oral options, patients should understand that these are not interchangeable treatments with equal strength or purpose

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The maintenance in the active state of pyruvate dehydrogenase complex that oxidizes pyruvate to acetyl CoA stimulates oxidative phosphorylation