John Gabe Horneff, an orthopedic surgeon at Pennsylvania Hospital, had noticed a peculiar trend: Some patients taking GLP-1s would come in with significant tendon injuries from relatively minor physical exertion
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The structure of liraglutide (a structurally distinct analog of GLP-1RA) was found to be unfavorable for co-formulation with SNAC on account of its stronger membrane-binding properties, which reduced transcellular passage, as well as its greater tendency to oligomerize, which countered the monomerizing effects of SNAC [56]
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