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Importantly, we found that addition of FXR-antagonistic BAs, including TMCA, HDCA or UDCA, could antagonize the effect of CDCA, a potent FXR agonist, on the mRNA expression of Shp and GLP-1 secretion in NCI-H716 cells (Fig

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Importantly, NICE does not recommend placing individuals with binge eating disorder on calorie-restricted diets as a standalone treatment, as this may worsen binge frequency

Dosing schedule is individualized based on clinical response and treatment goals Duration & Monitoring Program Duration Most patients participate for a minimum of 3 months, with many remaining on therapy for 6 to 12 months or longer depending on weight loss goals, metabolic health, and long-term maintenance plan Ongoing Monitoring Regular physician follow-up to assess progress, adjust dosing, monitor side effects, reinforce lifestyle modifications, and optimize long-term outcomes Results Expected Results Gradual, clinically meaningful weight reduction, decreased hunger and food noise, improved portion control, and improvements in metabolic health including blood glucose regulation and insulin sensitivity Results Timeline Appetite reduction often begins within the first several weeks, while meaningful weight loss develops progressively over several months

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