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The strength of evidence was rated as High, Medium, or Low, based on trial design and reproducibility of results
References Torbahn G, Brauchmann J, Axon E, et al
If tirzepatide is dampening dopamine reward signals, you might feel the negative effects of alcohol (nausea, fatigue, malaise) more prominently while experiencing less of the pleasurable effects (euphoria, relaxation, social lubrication)
It is rare, but it has been documented in tirzepatide users, making awareness essential
Second, undiagnosed hypothyroidism is common and directly affects weight loss
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