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To restore NAD + levels, ATM-deficient models were treated with NR, which stimulated PINK1-dependent mitophagy, reduced cytoplasmic DNA levels, and activated the NAD + -dependent SIRT1 signaling pathway, which in turn further promoted mitochondrial mitophagy and healthy morphology 111,288
An Pediatr (Engl Ed) 92, e1e377
Cellular energy dysfunction may contribute to depression through various pathways, leading to neurotoxicity and impaired neuroplasticity [4, 56]
Hu et al., Localized hydrophobicity in aqueous zinc electrolytes improves zinc metal reversibility
PubMed Wang W
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