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While oral supplements are convenient, they have drawbacks

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While GLP-1s have been largely studied and used for T2D, their benefits in T1D have not been explored as extensively

Within the GHSR1a-MC3R dimer, the GHSR1a inverse agonist SP-analog eliminates amplification of MC3R signaling (Rediger et al., 2011), an effect likely due to the dependence on GHSR1a constitutive activity