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The incidence and severity of high-altitude disease are determined by the attained altitude, ascent variables (including environmental and behavioral factors), and individual susceptibility

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Later, it was discovered that mitochondrial DNA encodes its own small biologically active peptides that are released from the mitochondria and act as hormone-like signaling molecules throughout the body

FIGURE 3 PEROXIREDOXINTHIOREDOXIN REDOX CYCLE Peroxiredoxins constitute a family of thiol-specific peroxidases that rely on thioredoxins (Trxs) as the hydrogen donor for the reduction of H 2 O 2 and lipid hydroperoxides ( 2 O 2 produced by the mitochondrial respiratory chain

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