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This microbial shift disrupts multiple gutbrain pathways simultaneously: these shifts coincided with gut barrier disruption (elevated serum endotoxin), triggering elevated hippocampal cytokines (IL-6, TNF-), which in turn suppress Tph2 expression and induce Tph2 hypermethylation (suggesting neuroinflammation and serotonergic suppression), ultimately manifesting as anxiety and depression-like behaviors (Buchenauer et al., 2023)
Udo Bhm ist Facharzt fr Allgemeinmedizin Naturheilverfahren, Sport- und Umweltmedizin und Friedrich Reuss ist Diplomchemiker und Assessor des Lehramtes
Reducing alcohol intake supports GSH and prevents ROS damage 49
They frequently present decreased caloric intake and increased metabolic requirements
