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One consistent finding is that peak tissue changes often lag weight loss, with maximal soft-tissue sagging commonly observed 6 to 12 months post-initial weight loss, aligning with clinical guidance that peak GLP-1 weight loss occurs at about 52 weeks

Front Bioeng Biotechnol 13:1645657 Yun C, Yuan Z, El Haddaoui-Drissi R, Ni R, Xiao Y, Qi Z et al (2025) Biomedical applications of functionalized composites based on metal-organic frameworks in bone diseases

2020;81:e46

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