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4.1 Central nervous system effects GLP-1R is distributed throughout various regions in the brain, with the highest concentrations being found in the hippocampus and cerebral cortex, areas mainly responsible for cognitive function, memory improvement, and learning ( GLP-1RA plays a key role in promoting CNS health in conditions like T2DM and lowering the risk of stroke ( In the brain, GLP-1RAs perform anti-inflammatory, antioxidant, and anti-apoptotic functions ( Appetite regulation is a common function of many GLP-1RAs, which act on the hypothalamus- the center of hunger and energy balance- and promote feelings of fullness, eventually leading to weight loss ( 4.2 Cardiovascular system effects GLP-1 receptor agonists have a very close connection with cardiovascular outcomes and prevention of many diseases

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To confirm whether the lipolytic action of AOD 9604 might merely be associated with the increased lipolytic receptor levels, additional studies were carried out where AOD 9604 was given to mice with knocked out lipolytic receptors

As hypothesized, this modification resulted in reduced internalization at the GLP-1R

Ibuprofen can exacerbate gastrointestinal symptoms by: Irritating the gastric mucosa NSAIDs reduce protective prostaglandins in the stomach lining Increasing ulcer risk particularly with prolonged use or higher doses Causing dyspepsia heartburn, indigestion, and upper abdominal discomfort Potentially worsening nausea adding to existing Wegovy-related symptoms Renal function considerations are also relevant