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Patients should contact their GP, prescriber, or anticoagulation clinic in the following circumstances: Before starting Mounjaro: Inform your prescriber about all medications you take, including anticoagulants Discuss your complete medical history, particularly any bleeding disorders or gastrointestinal conditions Ask about the monitoring plan and what symptoms to watch for During Mounjaro therapy: Severe or persistent gastrointestinal symptoms If nausea, vomiting, or diarrhoea prevents you from taking your anticoagulant or maintaining adequate fluid intake for more than 24 hours, seek same-day medical advice Signs of bleeding Any unusual bruising, bleeding that won't stop, blood in urine or stools, or unexplained bleeding from any site Significant weight loss Particularly relevant for warfarin users, as dose adjustments may be needed Missed doses If gastrointestinal side effects cause you to miss anticoagulant doses New medications Before starting any new prescription or over-the-counter medication When to seek emergency care (call 999 or go to A&E): Uncontrolled bleeding Head injury while taking anticoagulants Symptoms of stroke (facial weakness, arm weakness, speech problems) Severe, persistent abdominal pain (possible pancreatitis) Blood in vomit or black, tarry stools For warfarin users specifically , maintain your scheduled INR monitoring appointments and inform your anticoagulation service that you have started Mounjaro
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