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GLP-1 drugs are effective at reducing cytokine-driven inflammation because they activate AMPK, which, in turn, inhibits NF-kB activity, thereby decreasing cytokine production (9)

Clinical studies All 23 relevant clinical studies for this section focused on the effects of GLP-1RAs on cardiometabolic parameters in people with schizophrenia-spectrum disorders on antipsychotics, apart from a secondary analysis investigating cognitive and mental health outcomes 133 (Table 3 and Extended Data Tables 3 and 4)

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