Local injection carries additional risk of tissue irritation relative to subcutaneous administration away from injury
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Significant appetite reduction occurs by weeks 3 to 4, when the medication reaches therapeutic levels in your system
Now, fibromyalgia is making a potential appearance on this management list, according to a Medscape article Reporting on a large-scale health records analysis, the article states The use of GLP-1 receptor agonists was linked to lower pain and fatigue in patients with fibromyalgia The way that I use it in my practice these days is that if I have a patient with chronic pain or with fibromyalgia who has comorbidities that already have an FDA approval for GLP-1 use, such as obesity, diabetes, or obstructive sleep apnea, I would encourage them to go to their primary care physician and maybe consider getting started on a GLP-1, said presenter Nouran Eshak, MB ChB, of the Mayo Clinic in Scottsdale, Arizona. However, the article also lists several limitations to the study including Researchers were unable to account for confounders such as duration of illness, symptom severity, GLP-1 dosage, or access to healthcare. Disclaimer: This post is not a recommendation, rather just a report
A 2025 meta-analysis pooling three trials (878 participants) confirmed the pattern: significantly greater weight loss than placebo about ~14% of total body weight on average with no significant rise in overall adverse events [6] [7]
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