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Neuroscientist 22 , 447463 (2016)

Interestingly, the positive expression profiling of TGFBI with important ECM remodeling proteins such as GFPT2, FLNA, G6PD, ITGAV, ITGA1 and ITGA2 shown by TIMER datasets suggest a potential role of these proteins in remodeling ECM in response to carboplatin treatment

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Key themes shaping the next generation of therapies: Faster time to therapeutic dosing Reduced or eliminated titration schedules Improved tolerability and adherence Combination approaches targeting multiple metabolic pathways More patient-centric treatment design As innovation accelerates, the industry is shifting from a singular focus on efficacy toward a broader understanding of the full patient experience