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Daniel Bessesen, chief endocrinologist at the University of Colorado School of Medicine

Chemical analogues of GLP-1 are currently approved for the treatment of type 2 diabetes (T2D) and obesity 3,4

Upregulation of the downstream effectors of the insulin signalling pathway suggests that semaglutide treatment increases insulin sensitivity, a known effect of GLP-1R agonists that has not yet been shown on a cellular level in cardiomyocytes

33 Subsequently, the DRCR Protocol V showed that patients with CI-DME and vision of 20/25 or better could be closely monitored until they experienced worsening vision

Standard GLP-1 dosing is supported by randomized clinical trials, while microdosing has not been studied at those same levels