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Meanwhile, tirzepatide demonstrated a notable increase as well, with an ROR of 1.73 and a 95% CI of 1.42 to 2.09

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But without adequate testosterone, a substantial portion of that weight loss, potentially 15-40%, comes from muscle rather than fat

Third, the approval of orforglipron signals that non-peptide small molecules can replicate peptide receptor pharmacology, potentially disrupting the peptide therapeutics market for some targets