Front Endocrinol (Lausanne) 14:1234918
Skov K, Mandic IN, Nyborg KM
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220 found that the methylation levels of four ER genes including ERO1LB , NFE2L2 , MBTPS1 and EIF2AK4 which encoded ER oxidoreductin-1 (ERO1), nuclear factor-erythroid 2-related factor (Nrf2), site-1 protease (S1P) and eIF-2-alpha kinase (GCN2) respectively, were strongly correlated with total body fat levels
This process is closely linked to the activation of nuclear factor-B (NF-B) signaling and NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasomes, along with the release of pro-inflammatory cytokines, which can result in irreversible tissue damage (Andrade-Oliveira et al., 2019)