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F.VenneriA
My position is somewhat complex
Figure 3 In terms of the AMPK-mTOR/STAT3 pathway: Metformin can increase the AMP/ATP ratio in cells and activate AMPK, thus initiating a series of downstream metabolic and growth regulation reactions, such as the inhibition of mTOR ( In terms of the AMPK-FOX03 pathway: When AMPK is activated, it can further affect a variety of downstream targets, among which FOXO3 is a key transcription factor
C.FigueiredoC
Most clinical evidence is topical
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