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Occasionally, individuals experience temporary minor discomfort or sensitivity at injury sites during early treatment
doi:10.1073/pnas.0611137104 26
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It's a relatively uncommon side effect, affecting around 0.4% of people on semaglutide (around 4,000 out of every million people), so most studies only see a small handful of instances to examine
It usually produces less weight loss than tirzepatide, but it has the longest outcomes record in the class: fewer cardiovascular events, slower kidney decline, and years of diabetes-trial safety data
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