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7 This presents the idea that GLP-1 RAs exert effects beyond weight loss or glycemic control, perhaps acting locally on immune cells or keratinocytes
Neurology 60, 100107
Foxp3, which is highly expressed in Treg cells, can inhibit glycolysis related genes, and induce gene expression related to lipid and oxidative metabolism (11, 12)
These effects typically emerge during dose escalation and often diminish over several weeks as physiologic adaptation occurs
However, mitochondrial-encoded factors that actively regulate aging are unknown
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