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Cost discussions should still start with approval status and medical fit

The biomarker changes (lower blood pressure, better lipid profile) are favourable and create a reasonable prior expectation, but the dedicated cardiovascular outcomes trial (TRIUMPH-Outcomes) is not expected to report until late 2027 or early 2028

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Thats 4 to 8 pounds per month

Under normal circumstances, the mouth is protected by a delicately balanced bio-system of enzymes and lubricants in saliva, allowing beneficial bacteria to flourish and inhibit the growth of pathogenic bacteria