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As an obesity medicine physician scientist who regularly cares for patients with complex inflammatory conditions, this study reinforces what many of us have suspected clinically that the benefits of GLP-1 receptor agonists extend well beyond blood sugar control and weight loss and may fundamentally alter the disease trajectory for some of our highest-risk patients. Stanford, who was not involved in this research, is an obesity medicine physician scientist, educator and policy maker at Massachusetts General Hospital and Harvard Medical School, both in Boston

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1 Introduction Psoriasis (PsO) is a chronic, immune-mediated inflammatory skin disorder affecting 23% of the global population ( In parallel with this evolving disease concept, growing evidence points to a complex immunometabolic interplay linking dysregulated glucose metabolism, incretin biology, and chronic inflammation in PsO ( Within this framework, incretins particularly glucagon-like peptide-1 (GLP-1) have emerged as key immunometabolic regulators rather than merely glucose-lowering hormones