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have substantiated this view by demonstrating the efficacy of both topical and oral melatonin in the treatment of melasma, when used as an adjunct with other topical therapies.[] They also demonstrated the safety of oral melatonin up to a dose of 3 mg/day given for 90 days, except for the occurrence of mild, transient drowsiness in some patients

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Notably, MTs are expressed at higher levels in long-lived species and are also shown to be involved in neurodegenerative disorders [17,18,19]

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