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Clinical trials have shown that adding a GLP-1 drug to established metformin therapy produces greater weight loss and HbA1c reduction than either drug alone
Step 5: Consider a medication change Persistent, significant injection site reactions that do not respond to technique optimization and source changes may represent individual drug intolerance
Svensson et al., "The GH secre20260613-mnav1ogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats," J
Because of the GI effects, caution is advised in patients with severe gastroparesis (e.g., long-standing diabetic gastroparesis) GLP-1 RAs can worsen gastric emptying delays and are generally not recommended in that scenario
B12 Injections are considered safe, even in patients without a notable deficiency
