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However, the success of tirzepatide, which activates both GLP-1 and GIP receptors, demonstrated that dual agonism produces superior weight loss and glycemic control compared to GLP-1 agonism alone

GSH depletion in RPE cells increased the number of red puncta, indicating an increase in autophagic flux (Fig

In both of these studies, CagriSema was well-tolerated with an acceptable safety profile, with similar results reported in a phase 1b study in participants with overweight or obesity [7] and a phase 2 study in participants with type 2 diabetes [4]

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Yes, patients should inform their prescriber about all cannabis userecreational or medicinalto allow for individualised risk assessment, appropriate monitoring, and optimisation of treatment outcomes