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CLI was defined as persistent limb, foot or digit pain at rest or threatened tissue loss due to ischaemia (i.e., Fontaine classification III or IV ischaemia)
10.1038/s41388-022-02370-2 142 LiuY.SongZ.LiuY.MaX.WangW.KeY.et al (2021a)
Loss of GPX4 protein expression in NRF1-deficient cells sensitized cells to ferroptosis, whereas in cells lacking GPX4, overexpression of NRF1 failed to inhibit ferroptosis
Therefore, taking BPC-157 may have the following pros and cons: Oral BPC-157 Benefits Supporting Joint and Muscle tissue integrity Promoting muscle resilience and recovery Aids athletic performance Alleviating discomfort derived from overexertion Supporting cognitive function
