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More details Hide details 1 Sorbonne university, ACTION Study Group, INSERM UMRS_1166, Cardiology Institute, Piti Salptrire hospital (AP-HP) Paris, 75013 Paris, France., France 2 Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy., Italy 3 Universidade de So Paulo Faculdade de Medicina: So Paulo, SP, BR, Brazil 4 Department of Cardiology, CMC Ambroise Par, Neuilly-sur-Seine, France., France 5 University of Florida: Gainesville, Florida, US, United States 6 Collge National des Cardiologues Franais, 13 rue Niepce, 75014 Paris, France, France 7 Jesselson Integrated Heart Center, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Israel, Israel 8 Policlinico Casilino, Italy 9 Department of Clinical and Experimental Medicine, University of Messina, Italy, Italy 10 Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland, Poland 11 Department of Cardiology, Assistance Publique-Hpitaux de Paris, Henri Mondor University Hospital, Crteil, France, France Submission date: 2026-05-27 Final revision date: 2026-07-19 Acceptance date: 2026-07-26 Online publication date: 2026-07-26 Corresponding author Pierre Franois Sabouret Sorbonne university, ACTION Study Group, INSERM UMRS_1166, Cardiology Institute, Piti Salptrire hospital (AP-HP) Paris, 75013 Paris, France., France Introduction: Not applicable

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Obesity rates RGAs obesity rate projections for the US non-diabetic population in 20 years (2045) are shown below, both for the baseline scenario (without the medications) and the central scenario (with the medications): For ages 20-90, the model estimates an approximate reduction in obesity prevalence of about 12% for central assumptions relative to the baseline scenario