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Peripherally administered liraglutide has direct access to a limited number of brain regions, primarily circumventricular organs and a few sites in the hypothalamus (8), and CNS GLP-1Rs are important for its body weightlowering (BW-lowering) effect (9)

This pattern is usually self-limiting and resolves as the body establishes a new hormonal equilibrium

At the molecular level, NdO exposure activates the PI3K/Akt signaling pathway, upregulating inflammatory cytokines and fibrosis-related genes, and can modulate exosomal RNA expression to affect the tissue microenvironment (51)

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