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Fold changes in gene expression, scatterplots, and heatmaps were analyzed and generated according to the RT 2 PCR array data analysis website ( 13 C 3 -lactate metabolic flux analysis 1 10 7 MCF7 AR/Ad cells ( n = 6 biologically independent samples) cultivated in regular complete RPMI 1640 medium containing 10 mM 13 C 3 -lactate for 12 h were pelleted, stored at 80 C, and then sent to Metabo-Profile Inc (Shanghai, China) for metabolic flux assay using ultra-performance liquid chromatography triple-quadrupole mass spectrometry (UPLC-TQ-MS), with unlabeled AR and Ad cells collected at 0 h being used to correct for the natural isotopic abundance that could potentially contribute to false positives

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