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The basal insulin secretion without GLP-1 and GIP infusion also increased, suggesting that intensive insulin therapy improved -cell function in general and -cell incretin sensitivity in particular

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ZhangZ,ZhangB,WangXetal.Olfactory Dysfunction Mediates Adiposity in Cognitive Impairment of Type 2 Diabetes: Insights from Clinical and Functional Neuroimaging Studies.Diabetes Care.2019;42(7):1274-83

Heres how specific conditions can impact the use of B12 shots: Heart Disease: While B12 is essential for overall health, excessive amounts of vitamin B12 in the body may sometimes cause an increase in certain heart disease risk markers, particularly for individuals with pre-existing cardiovascular conditions