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This work was supported, in part, by the National Institute of Child Health and Development (RO1 HD051873 to SJJ) and the Jane Botsford Johnson Foundation

SAMe is the primary methyl donor in the body, while methionine is an essential amino acid that is converted to SAMe in the body

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409 Complementarily, IL-17F promote the expression of TGF1 in adipocytes, which fosters sympathetic innervation and suggests a novel therapeutic target for obesity that could stimulate thermogenic activity in fat tissue, thereby improving metabolic health and providing a potential treatment strategy for obesity and its related metabolic disorders

This process converts glutamate (the principal excitatory neurotransmitter) into GABA (the principal inhibitory neurotransmitter)