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Crucially, this study shifted the scientific paradigm from a simple model of "glutathione depletion" to a model of an "overwhelmed compensatory mechanism." The discovery that circulating immune cells in these patients actually have elevated glutathione levelswhile simultaneously suffering from a severe depletion of other protective enzymes like SOD2revealed that the cells are desperately, and unsuccessfully, trying to fight off a catastrophic level of oxidative damage
It's popular in biohacking circles and often pops up in patient consults, but the FDA hasn't approved it for human therapy
Biotechnol Bioprocess Eng 20:887893
doi: 10.1016/j.fertnstert.2012.10.042 76 JannatifarRPiroozmaneshHJalalabadiFNMomeniHR
(2) J M Monti, J Debellis, P Alterwain, T Pellejero, et al (1987) Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs International Journal of Clinical Pharmacological Research, 1987, Volume 7 (Issue 2), Pages 105-10
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