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Importantly, several phytochemicals demonstrate metabolic benefits by enhancing GLP-1/GIP signaling through DPP-IV inhibition, providing a biologically plausible route for synergistic neuroprotection in PD (Singh et al., 2020

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Thus, studies in mice have revealed a multistep metaorganismal pathway that is initiated by sequential gut microbiotadependent conversions of oral l-carnitine into an atherogenic intermediate, BB, which is then converted into TMA, the immediate precursor for host hepatic transformation into TMAO (i.e., l-carnitine BBTMATMAO)

However, the amount of glutathione available from foods may be influenced by factors such as cooking methods and digestion