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A 2024 study in The Lancet indicates that this dual-action approach may lead to even greater reductions in food noise than GLP-1 alone

But real-world stories tell a different tale

Probiotics for managing GLP-1 medication side effects Research indicates that specific probiotic strains may alleviate GI side effects associated with GLP-1 RAs: Diarrhea : Saccharomyces boulardii has demonstrated efficacy in reducing antibiotic-associated diarrhea 13 and may help manage diarrhea induced by GLP-1 RAs

At this point, domperidone should be preferred over metoclopramide due to the risk of extrapyramidal side effects