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By Lana Pine | Published on September 16, 2025 4 min read Overall, GLP-1 receptor agonists (GLP-1 RAs) appear to be effective and relatively safe for kids and teens, at least in the short term, in helping with blood sugar control, weight and heart-related health risks, according to a new study published in JAMA Pediatrics

Richard DiMarchi, one of the pioneers of GLP-1 drugs, argues that the degree which they have helped to manage excess body weight compares with the historic breakthroughs in the management of excess blood pressure, excess lipids and excess glucose

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GLP-1 is a type of incretin hormone, meaning its created in the gut and released after eating a meal