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However, achieving therapeutic accumulation in the posterior segment following conventional eye drop has proven difficult and is often considered the holy grail of ocular drug delivery
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7.1 Identification of gutliver axisrelated therapeutic targets The future studies to systematically identify key molecular targets involved in gutliver communication during cadmium exposure, including intestinal barrier regulators, bile acid signaling pathways, microbial metabolites, and inflammatory mediators, which may serve as potential intervention targets
In humans, cardioprotective effects are partly attributed to reduced myocardial autophagy and apoptosis via the AMPK/mTOR pathway (26)
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