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Sustained denervation leads to progressive atrophy, myocyte death, and fibrosis with irreversible muscle impairment

FOXO4-DRI: Senolytic Peptide Mechanism and the p53-FOXO4 Axis FOXO4-DRI is a D-retro-inverso peptide that selectively kills senescent cells by disrupting the protective FOXO4-p53 interaction

There is one open-label intravenous safety pilot in two healthy adults, who received single doses of 10 mg and 20 mg with no comparator, no blinding, and short-term observation limited to vital signs, self reported symptoms and labs across two days [4]

TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3