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The compound activates HGF/c-Met signaling in hippocampal and cortical regions at picomolar to nanomolar concentrations, suggesting efficient distribution to the brain regions most relevant to learning and memory

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Eli Lilly is studying retatrutide in several phase-3 clinical trials for obesity, type-2 diabetes, knee osteoarthritis pain, moderate-to-severe obstructive sleep apnea, chronic low back pain, cardiovascular and renal outcomes, and metabolic dysfunction-associated steatosis liver disease

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