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In a human trial involving over 70 subjects, no adverse effects of DSIP (cardiovascular, respiratory, metabolic) were observed

Emerging evidence demonstrates that miRNAs are critical regulators of lipid synthesis and FAO 81 resulting in defective cell metabolism and carcinogenesis 82 directly targeting key enzymes or transcription factors as oncogenes and tumor suppressors 81 as shown in Table 1

1 In the LEADER (NCT01179048) and REWIND (NCT01394952) trials, liraglutide in patients with T2D and high cardiovascular risk and dulaglutide in a broad T2D population, respectively, improved composite renal outcomes

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