In midlife, it is important to get clear on the goals of nutrition and lifestyle interventions
A phase 2 study in subjects having BMI 27 kg/m 2 without T2D finds a mean body weight loss ranging from 9.4% to 14.7% across four doses (12, 24, 36, or 45 mg), versus 2.3% with placebo at 36 weeks ( 2 , orforglipron at the maximum dose of 45 mg produces a statistically significant glycated hemoglobin (HbA1c) reduction of 2.1%, versus 0.4% with placebo and 1.1% with dulaglutide 1.5 mg ( Results from the 40-week phase 3 ACHIEVE-1 trial in participants with obesity and poorly controlled T2D shows mean weight loss of 4.7%, 6.1%, 7.9% and 1.6% for groups receiving 3 mg, 12 mg, 36 mg, and placebo, respectively ( 3.1.2.2 Aleniglipron (GSBR-1290) Aleniglipron is an oral small molecule GLP-1 RA
Each compound is listed with its proportion of the total vial content so you know exactly what you're working with before the calculation runs
Labs are recommended but not required to start treatment
New Phytol