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British Medical Journal , 2009, 338: a3083

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For severe obesity, a 15% weight loss, while clinically significant, may still leave substantial cardiometabolic risk behind

Weight Loss: While weight loss can be a desirable outcome for many individuals with type 2 diabetes, excessive weight loss associated with GLP-1 medications may be problematic for some patients, especially those who are already at a healthy weight or at risk of malnutrition

It is not effective against visceral fat, which surrounds the internal organs beneath the muscle wall