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When repeated administration is expected to be relevant for the future therapeutic use of the compound, the study may subsequently progress to a Multiple Ascending Dose (MAD) phase

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In metabolic disorders such as type 2 diabetes (T2D), microbial dysbiosis is characterized by an increase in Gram-negative Enterobacteriaceae and a reduction in short-chain fatty acid (SCFA)-producing bacteria such as Bifidobacterium, resulting in elevated circulating LPS levels and metabolic endotoxemia (Nguyen et al., 2014)

This argument hinges on the understanding that dehydration can lead to a concentration of alcohol in the blood, potentially pushing BAC readings over the legal limit

However, the process of making ATP also produces reactive oxygen species (ROS), such as hydrogen peroxide, which can damage the cell at higher levels