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Eur J Pharmacol (2012) 674(2-3):2806

Hydration support GLP1 medications can sometimes lead to dehydration, especially if your fluid intake drops along with your appetite

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However, prolonged CR may diminish turnover in this compartment, occasionally yielding modest gains in trabecular indices as seen in female C57BL6J mice undergoing 30% CR during their vulverable period of accelerated bone resorption (i.e., between 8 and 16 weeks)