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Studies have evaluated how multi-receptor signaling influences the relative distribution of fat mass and lean tissue in metabolic models, with body composition assessments used to track changes in adipose tissue, regional fat depots, and lean mass during controlled investigations

Cagrilintide targets the amylin receptor, whereas GLP-1 agonists target glucagon-like peptide-1 pathways

12 Yilmaz B, Macpherson AJ

Nausea, which affected 18-36% of participants at the 4 mg dose and 17-60% at the 8 mg dose in clinical trials, usually peaks during the first week of each new dose level and then subsides as the body adapts

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