In clinical trials, the most common observations were gastrointestinal effects: nausea (44.2% vs 17.4% placebo in STEP 1), diarrhea (30.0%), vomiting (24.8%), and constipation (24.2%)
An in-use pen can be kept at room temperature (up to 86F) or in the refrigerator for up to 56 days
Finally, in 2022, EMPA-KIDNEY showed that empagliflozin provided benefit in patients with CKD without regard for diabetes or proteinuria
However, semaglutide can still be an effective weight loss medication for adults, especially when combined with a healthy diet and exercise
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