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5 STEP 2 evaluated 1,210 participants with type 2 diabetes and randomized them to receive either 1.0 mg semaglutide, 2.4 mg semaglutide, or placebo

In ATTAIN-2 , which specifically studied people with both obesity and type 2 diabetes (a group for whom weight loss is known to be harder), participants on the highest dose lost an average of 10.5% of body weight (about 23 lbs) over 72 weeks, while also reducing A1C by an average of 1.8%

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(2019) further demonstrated that recombinant human GLP-1 (rhGLP-1) suppresses epithelial apoptosis and mitigates tubulointerstitial fibrosis via the PKA/PKC signaling pathway (Yin et al., 2019)

CJC-1295 is a potent GHRH analogue known for its extended half-life, allowing sustained GH release in experimental models