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Ex-4 or vehicle was perfused through the microdialysis probe concurrently with cocaine (Supplementary Figure 2B)
However, the potential gastrointestinal side effects, including the risk of acid reflux due to delayed gastric emptying, present a challenge in its clinical use
However, owing to the lack of consideration for brain capillary binding or sequestration, the reliability of these results regarding brain uptake pharmacokinetics has been questioned [21] as well as whether results could be translated into humans
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