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When coupled to -arrestins, GPCRs are desensitized by abrogated coupling to G proteins and trafficked away from the cell surface, destined for either re-sensitization following their recycling back to the plasma membrane, or for final signal termination resulting from their degradation in lysosomes (McCorvy et al., 2017)

Seek urgent same-day medical attention if you develop severe, persistent abdominal pain (especially if radiating to the back), as this could indicate acute pancreatitis, a rare but serious complication of GLP-1 therapy

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