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Der Wirkmechanismus von GHK-Cu beruht auf mehreren miteinander verknuepften Signalwegen
seven in absentia homolog 2 (SIAH2), a key regulator, together with hypoxia-inducible factor 1 alpha (HIF-1), of the cellular hypoxic responses under pathological conditions such as ischemia-reperfusion, whose association with NRF2 causes the degradation of NRF2 irrespective of its phosphorylation status [230]
However, feeding these mice with high fat jelly diet prevented their gastrointestinal problems and their death was reported to be due to TDP-43 pathology mediated degeneration, and not due to gastrointestinal problems 75,76
Kano, Y
AyalaAMuozMFArgellesS
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