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Why Am I So Hungry on Retatrutide
In SURMOUNT 4, all participants received the maximum tolerated dose of tirzepatide for 36 weeks and were then randomized 1:1 to continue tirzepatide or receive placebo until 88 weeks
What to expect at 4 weeks: Slight lightening or softening of uneven skin tone Improved skin hydration or smoother texture Some reduction in dullness or fatigue (if oxidative stress was high) Minimal but measurable improvement in antioxidant biomarkers Its important: at 4 weeks, changes are mild and gradual
Discard without exception
In mice single-cell RNA sequencing identified a subpopulation of GLP-1R-positive memory T-cells that was mainly composed of exhausted CD8+ T cells: functionally, stimulation of the GLP-1R on these cells was found to mediate apoptosis and anergic signals, thereby suppressing effector T-cell function and the inflammatory response (49, 50)
